Vaccine/Diagnostics Development Pipelines
SARS-CoV-2 Peptide Vaccine, Gen 10
Software for in silico identification of immunologically-vulnerable regions of the HCV E2 glycoprotein and broadly neutralizing antibodies that target them
Three-dimensional mRNA optimization algorithm that simultaneously optimizes CAI, CPB, and MFE parameters. Based on research from Tsinghua University.
A project focused on the in silico design of a multi-epitope peptide vaccine against Monkeypox virus (MPXV) using immunoinformatics, epitope prediction, and molecular docking with TLR4.
This Python script generates multi-epitope vaccine constructs by combining permutations of cytotoxic T lymphocyte (CTL), helper T lymphocyte (HTL), and B cell epitopes. It uses linkers and adjuvants to create unique constructs, which are saved in FASTA format for further analysis.
Peptide Vaccine Analysis Tool (PVAT) is an optimization software that predicts the best possible peptide stretches in a given protein sequence based on two factors: 1. the surface exposure of the peptide stretches, and 2. their susceptibility to mutation.
Fall 2020 - Computational Medicine - course project
Immune Control Architecture (ICA): a computational scoring framework for dengue vaccine epitope design.
Group project for Fall 2020 Computational Medicine course.
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