Compute R-squared between allele dosages of two sets of genotypes#190
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Compute R-squared between allele dosages of two sets of genotypes#190szhan wants to merge 1 commit into
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Note also that the R-squared statistic is calculated on groups of variants within a MAF bin ("aggregate R2"). |
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R-squared between the allele dosage of imputed genotypes and the allele dosage of truth genotypes is a commonly used metric for evaluating the performance of imputation methods. It has been shown that improvements in R-squared can translates to increases in statistical power of GWAS.