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Releases: MarcusFFFFFF/dna-null-framework

v0.1.0 — Initial framework release

19 May 09:15
@MarcusFFFFFF MarcusFFFFFF
v0.1.0
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v0.1.0 — Initial framework release Latest
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First public release of the DNA null framework.

What's included

  • Framework (src/): v8 analysis engine, v11 dual-null wrapper, v12 diagnostics
  • Documentation (docs/): Preprint outline for MECP2 case study
  • Figures (figures/): Four preprint figures including π-validation and MECP2 dual-null analysis
  • Results (results/): Z-score JSON outputs from N=100 shuffles

Method validation

  • π-derived DNA returns |Z|<3 across all twelve metrics under both null modes
  • Peng et al. (1992) long-range correlations reproduced cleanly on chr1 intergenic reference

Case study finding

MECP2 mRNA shows DFA Hurst Z=+5.54 under both mono and dinucleotide null modes, demonstrating long-range correlation structure independent of dinucleotide composition. Residual 8-mer reverse-complement asymmetry (Z=+9.18 under dinucleotide null) survives Bonferroni correction over 440 tests.

Honest limitations

  • Single-gene case study; broader panels require length-matched, repeat-screened controls
  • See diagnostics_v12.json for full repeat-screening output across the panel
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