"Any new TBI prediction model that cannot demonstrate calibration superiority over IMPACT Core and CRASH Basic has not earned clinical deployment."
| Attribute | Value |
|---|---|
| Status | Incubating |
| Maturity | Design Phase |
| License | Apache-2.0 |
| Part of | Evidence Commons |
| Mission Pillar | Pillar 1 (Clinical AI Evaluation & Benchmarking) |
BRIDGE (Biomarker-Ready Infrastructure for Deploying Guideline-Aligned Evidence) is clinical decision support infrastructure for traumatic brain injury. BRIDGE-TBI-Lite is the planned open-source extraction containing validated TBI clinical decision rules, benchmark baselines, and evaluation tooling. The system is designed to enforce methodological discipline: any new model must demonstrate improvement over established baselines (IMPACT Core, C-statistic ~0.78-0.82 for mortality; CRASH Basic) using net reclassification improvement as the preferred comparison metric, with calibration superiority weighted above discrimination.
The parent codebase contains decision logic across the platform (evidenceos-health-platform) and research repository (evidenceos-research/evidenceos-tabular), including conformal prediction intervals for uncertainty quantification and NINDS CDE-compliant input/output schemas. No standalone extraction exists yet. This repository is intended to hold the extracted, independently usable decision rule implementations with sample size validation enforcing Riley et al. (2019/2020) criteria.
Regulatory note: BRIDGE provides clinical decision support (CDS) infrastructure. "Neurodiagnostic" describes domain positioning, not an FDA-cleared diagnostic claim.
| Component | Description | Platform Status |
|---|---|---|
| Decision Rules | Executable clinical decision rules (Canadian CT Head, PECARN, CHIP, others) | Designed |
| Baseline Models | IMPACT Core + CRASH Basic reference implementations | Designed |
| Conformal Intervals | MondrianCQR uncertainty quantification from evidenceos-conformal |
Parent code exists |
| CDE Schema | NINDS CDE v3.0 compliant input/output definitions from evidenceos-ontology |
Parent code exists |
| Sample Size Validator | Riley pmsampsize calculation (EPV >= 10 necessary but not sufficient) | Parent code exists |
| NRI Calculator | Net reclassification improvement for model comparison | Designed |
What exists in the parent codebase:
- Conformal prediction modules in
evidenceos-research/evidenceos-conformal(MondrianCQR + 5 modules) - NINDS CDE ontology schemas (13 YAML files, 7,780 lines)
- Tabular prediction pipeline in
evidenceos-research/evidenceos-tabular - 12-axis multiverse engine (927 cells across 13 configs, 99.0% passing)
What does not exist yet:
- Standalone extracted decision rule library
- IMPACT Core and CRASH Basic reference implementations
- NRI comparison tooling
- INT-05 integration (BRIDGE feeding Clinical Arena for evaluation gating)
- Test suite or CI pipeline for this repository
- Implement IMPACT Core and CRASH Basic as reference Python modules with published coefficients
- Extract conformal prediction interface from
evidenceos-conformal - Define NINDS CDE-compliant input schema as standalone JSON/YAML
- Build NRI calculator for head-to-head model comparison
- Integrate Riley sample size validation as a pre-analysis gate
- Publish v0.1.0 with baseline models, CDE schema, and comparison tooling
graph LR
A[evidenceos-conformal<br/>MondrianCQR] --> B[BRIDGE-TBI-Lite]
C[evidenceos-tabular<br/>multiverse engine] --> B
B -->|INT-05| D[Clinical Arena<br/>evaluation gate]
B -->|INT-04| E[Evidence Capsules<br/>confidence scoring]
style B fill:#2A9D8F,stroke:#1E3A8A,color:#fff
BRIDGE-TBI-Lite is part of the Clinic-in-a-Box product family. The full BRIDGE platform integrates with Evidence Capsules for confidence scoring (INT-04, not built) and Clinical Arena for model evaluation gating (INT-05, not built).
Canonical source: EvidenceOS/evidenceos-health-platform + evidenceos-research/evidenceos-tabular
This project is not yet accepting contributions. The decision rule extraction and baseline model implementations are under active design. See CONTRIBUTING.md for future plans.
Apache-2.0 — see LICENSE for details.