Should batch correction be performed before calculating methylation age using this package?

[YichenTao]

I did not correct for methylation and used the following code to calculate methylation age. The results are sh

10.Clock.BMIQ.sam57.tif

own in the figure.

[YichenTao]

“ chip_clock <- DNAmAge(
tmp_beta,
clocks = "all",
toBetas = FALSE,
fastImp = TRUE,
normalize = FALSE,
age = matched_age, # 使用对齐后的 age
cell.count = FALSE,
min.perc = 0.8
)”

I did not correct for methylation and used the following code to calculate methylation age. The results are sh

10.Clock.BMIQ.sam57.tif

own in the figure.