We currently backtranslate the final pVACvector vector peptide sequence from AA -> DNA via a simple lookup table. This process should be improved to take into account all possible codons and pick the most likely one. There are some tools that do so for AA -> mRNA backtranslation:
We want to add AA -> mRNA backtranslation to pVACvector. The existing AA -> DNA backtranslation via codon lookup could then be replaced by using the mRNA sequence and replacing Us with Ts.
We currently backtranslate the final pVACvector vector peptide sequence from AA -> DNA via a simple lookup table. This process should be improved to take into account all possible codons and pick the most likely one. There are some tools that do so for AA -> mRNA backtranslation:
We want to add AA -> mRNA backtranslation to pVACvector. The existing AA -> DNA backtranslation via codon lookup could then be replaced by using the mRNA sequence and replacing Us with Ts.