diff --git a/src/coreclr/tools/Common/InstructionSetHelpers.cs b/src/coreclr/tools/Common/InstructionSetHelpers.cs
index 7dcf031a9e0131..b1ff24e8b804f7 100644
--- a/src/coreclr/tools/Common/InstructionSetHelpers.cs
+++ b/src/coreclr/tools/Common/InstructionSetHelpers.cs
@@ -31,7 +31,10 @@ public static InstructionSetSupport ConfigureInstructionSetSupport(string instru
 
             if ((targetArchitecture == TargetArchitecture.X86) || (targetArchitecture == TargetArchitecture.X64))
             {
-                if (isReadyToRun && targetOS != TargetOS.OSX && targetOS != TargetOS.MacCatalyst)
+                bool isAppleOS = targetOS is TargetOS.OSX or TargetOS.MacCatalyst
+                    or TargetOS.iOSSimulator or TargetOS.tvOSSimulator;
+
+                if (isReadyToRun && !isAppleOS)
                 {
                     // ReadyToRun can presume AVX2, BMI1, BMI2, F16C, FMA, LZCNT, and MOVBE
                     instructionSetSupportBuilder.AddSupportedInstructionSet("x86-64-v3");
diff --git a/src/coreclr/vm/ceeload.cpp b/src/coreclr/vm/ceeload.cpp
index 620ccc1844f1aa..51e7e674c0eb93 100644
--- a/src/coreclr/vm/ceeload.cpp
+++ b/src/coreclr/vm/ceeload.cpp
@@ -3583,6 +3583,14 @@ void Module::RunEagerFixupsUnlocked()
             {
                 _ASSERTE(IsReadyToRun());
                 GetReadyToRunInfo()->DisableAllR2RCode();
+
+#ifndef FEATURE_DYNAMIC_CODE_COMPILED
+                if (GetReadyToRunInfo()->HasStrippedILBodies())
+                {
+                    EEPOLICY_HANDLE_FATAL_ERROR_WITH_MESSAGE(COR_E_EXECUTIONENGINE,
+                        W("ReadyToRun code was disabled by a failed eager fixup, but the image has stripped IL bodies and this runtime has no JIT fallback."));
+                }
+#endif // !FEATURE_DYNAMIC_CODE_COMPILED
             }
             else
             {
diff --git a/src/coreclr/vm/codeman.cpp b/src/coreclr/vm/codeman.cpp
index 0ae31afb30ebef..eda07ee2a9cbb8 100644
--- a/src/coreclr/vm/codeman.cpp
+++ b/src/coreclr/vm/codeman.cpp
@@ -1331,7 +1331,12 @@ void EEJitManager::SetCpuInfo()
     uint32_t maxVectorTBitWidth = (CLRConfig::GetConfigValue(CLRConfig::EXTERNAL_MaxVectorTBitWidth) / 128) * 128;
 
 #if defined(FEATURE_INTERPRETER)
-    if (maxVectorTBitWidth != 128 && CLRConfig::GetConfigValue(CLRConfig::EXTERNAL_InterpMode) == 3)
+#if defined(FEATURE_DYNAMIC_CODE_COMPILED)
+    bool interpreterOnly = CLRConfig::GetConfigValue(CLRConfig::EXTERNAL_InterpMode) == 3;
+#else
+    bool interpreterOnly = true;
+#endif
+    if (maxVectorTBitWidth != 128 && interpreterOnly)
     {
         // Disable larger Vector<T> sizes when interpreter is enabled
         maxVectorTBitWidth = 128;
@@ -1701,14 +1706,6 @@ void EEJitManager::SetCpuInfo()
 
     uint32_t preferredVectorBitWidth = (CLRConfig::GetConfigValue(CLRConfig::EXTERNAL_PreferredVectorBitWidth) / 128) * 128;
 
-#ifdef FEATURE_INTERPRETER
-    if (CLRConfig::GetConfigValue(CLRConfig::EXTERNAL_InterpMode) == 3)
-    {
-        // Disable larger Vector<T> sizes when interpreter is enabled, and not compiling S.P.Corelib
-        preferredVectorBitWidth = 128;
-    }
-#endif
-
     if ((preferredVectorBitWidth == 0) && throttleVector512)
     {
         preferredVectorBitWidth = 256;
diff --git a/src/coreclr/vm/readytoruninfo.h b/src/coreclr/vm/readytoruninfo.h
index e31a36b1234d35..8127e05f6385fd 100644
--- a/src/coreclr/vm/readytoruninfo.h
+++ b/src/coreclr/vm/readytoruninfo.h
@@ -249,6 +249,12 @@ class ReadyToRunInfo
         return m_pHeader->CoreHeader.Flags & READYTORUN_FLAG_PARTIAL;
     }
 
+    BOOL HasStrippedILBodies()
+    {
+        LIMITED_METHOD_CONTRACT;
+        return m_pHeader->CoreHeader.Flags & READYTORUN_FLAG_STRIPPED_IL_BODIES;
+    }
+
     void DisableAllR2RCode()
     {
         LIMITED_METHOD_CONTRACT;