diff --git a/src/tests/JIT/Directed/tailcall/mutual_recursion.fs b/src/tests/JIT/Directed/tailcall/mutual_recursion.fs
index 43147f27d17086..ac6a167c1167a5 100644
--- a/src/tests/JIT/Directed/tailcall/mutual_recursion.fs
+++ b/src/tests/JIT/Directed/tailcall/mutual_recursion.fs
@@ -556,7 +556,6 @@ type Driver() =
 ////////////////////////////////////////////////////////////////////////////////
 ////////////////////////////////////////////////////////////////////////////////
 
-[<ActiveIssue("https://github.com/dotnet/runtime/issues/127437", typeof<PlatformDetection>, [| "IsBrowser" |])>]
 [<SkipOnCoreClr("Unstable under JIT stress", RuntimeTestModes.AnyJitStress ||| RuntimeTestModes.AnyGCStress)>]
 [<SkipOnMono("Not supported on Mono runtime")>]
 [<ConditionalFact(typeof<Utilities>, [| "IsNotNativeAot" |])>]
diff --git a/src/tests/JIT/Directed/tailcall/mutual_recursion.fsproj b/src/tests/JIT/Directed/tailcall/mutual_recursion.fsproj
index e94909d41ed937..9c14bde0bab0cd 100644
--- a/src/tests/JIT/Directed/tailcall/mutual_recursion.fsproj
+++ b/src/tests/JIT/Directed/tailcall/mutual_recursion.fsproj
@@ -6,6 +6,8 @@
   <PropertyGroup>
     <Optimize>True</Optimize>
     <TargetFramework>$(NetCoreAppToolCurrent)</TargetFramework>
+    <!-- F# does not emit tail calls in Debug builds, leading to stack overflow. See https://github.com/dotnet/runtime/issues/127437 -->
+    <DisableProjectBuild Condition="'$(Configuration)' == 'Debug'">true</DisableProjectBuild>
   </PropertyGroup>
   <ItemGroup>
     <Compile Include="mutual_recursion.fs" />