Seems to happen at the main menu load or on main menu with map texture failing to load - I've isolated this error that i've seen a few times. Loading is much less uneventful with map texture replacer not loaded.
Fallback handler could not load library C:/Steam/steamapps/common/Cities Skylines II/Cities2_Data/MonoBleedingEdge/data-0000022D3E105920.dll
Fallback handler could not load library C:/Steam/steamapps/common/Cities Skylines II/Cities2_Data/MonoBleedingEdge/data-0000022F2D71A190.dll
Fallback handler could not load library C:/Steam/steamapps/common/Cities Skylines II/Cities2_Data/MonoBleedingEdge/data-0000022F2D765A20.dll
Fallback handler could not load library C:/Steam/steamapps/common/Cities Skylines II/Cities2_Data/MonoBleedingEdge/data-0000022F2D7A66F0.dll
Fallback handler could not load library C:/Steam/steamapps/common/Cities Skylines II/Cities2_Data/MonoBleedingEdge/data-0000022DDED38040.dll
[Modding] [ERROR] Error initializing mod MapTextureReplacer, Version=1.0.0.0, Culture=neutral, PublicKeyToken=null (MapTextureReplacer, Version=1.0.0.0, Culture=neutral, PublicKeyToken=null) System.IO.IOException: The process cannot access the file because it is being used by another process.
at System.IO.LongFile.GetFileHandle (System.String normalizedPath, System.Guid guid, System.IO.FileMode mode, System.IO.FileAccess access, System.IO.FileShare share, System.IO.FileOptions options) [0x00035] in <6af4bcb8ebe247b1981418a048411c4f>:0
at System.IO.LongFile.Open (System.String path, System.IO.FileMode mode, System.IO.FileAccess access, System.IO.FileShare share, System.Int32 bufferSize, System.IO.FileOptions options, System.Action disposeCallback) [0x00017] in <6af4bcb8ebe247b1981418a048411c4f>:0
at System.IO.LongFile.Open (System.String path, System.IO.FileMode mode, System.IO.FileAccess access, System.IO.FileShare share, System.Action disposeCallback) [0x00000] in <6af4bcb8ebe247b1981418a048411c4f>:0
at System.IO.LongFile.OpenReadWrite (System.String path, System.Action disposeCallback) [0x00000] in <6af4bcb8ebe247b1981418a048411c4f>:0
at Colossal.IO.AssetDatabase.FileSystemDataSource.GetWriteStream (Colossal.Hash128 id) [0x000a8] in :0
at Colossal.IO.AssetDatabase.AssetDatabase`1[T].GetWriteStream (Colossal.Hash128 id) [0x00000] in :0
at Colossal.IO.AssetDatabase.Internal.SaveSettingsHelper.GetWriteStream (Colossal.IO.AssetDatabase.SettingAsset+Fragment fragment) [0x00020] in :0
at Colossal.IO.AssetDatabase.SettingAsset.SaveNow (System.Boolean saveAll, System.Boolean cleanupSettings, Colossal.IO.AssetDatabase.Internal.SaveSettingsHelper helper) [0x0009e] in :0
at Colossal.IO.AssetDatabase.AssetDatabase.SaveSettingsNow () [0x00023] in :0
at MapTextureReplacer.Systems.MapTextureReplacerSystem.SetTextureSelectDataJson () [0x00021] in C:\Users\Cgameworld\source\repos\MapTextureReplacer\Systems\MapTextureReplacerSystem.cs:163
at MapTextureReplacer.Systems.MapTextureReplacerSystem.OnCreate () [0x00021] in C:\Users\Cgameworld\source\repos\MapTextureReplacer\Systems\MapTextureReplacerSystem.cs:54
at Unity.Entities.ComponentSystemBase.CreateInstance (Unity.Entities.World world) [0x00093] in <42dd0aeaaef34ed8acb4b4fe5f093234>:0
at Unity.Entities.World.AddSystem_OnCreate_Internal (Unity.Entities.ComponentSystemBase system) [0x00011] in <42dd0aeaaef34ed8acb4b4fe5f093234>:0
at Unity.Entities.World.CreateSystemInternal (Unity.Entities.SystemTypeIndex type) [0x0000f] in <42dd0aeaaef34ed8acb4b4fe5f093234>:0
at Unity.Entities.World.GetOrCreateSystemManaged (Unity.Entities.SystemTypeIndex typeIndex) [0x0000b] in <42dd0aeaaef34ed8acb4b4fe5f093234>:0
at Unity.Entities.World.GetOrCreateSystemManaged[T] () [0x00028] in <42dd0aeaaef34ed8acb4b4fe5f093234>:0
at Game.UpdateSystem.UpdateAt[SystemType] (Game.SystemUpdatePhase phase) [0x00018] in <24020fbca57c414fa88795539296438c>:0
at MapTextureReplacer.Mod.OnLoad (Game.UpdateSystem updateSystem) [0x00096] in C:\Users\Cgameworld\source\repos\MapTextureReplacer\Mod.cs:40
at Game.Modding.ModManager+ModInfo.OnLoad (Game.UpdateSystem updateSystem) [0x00015] in <24020fbca57c414fa88795539296438c>:0
at Game.Modding.ModManager+ModInfo.Load (Game.UpdateSystem updateSystem) [0x00122] in <24020fbca57c414fa88795539296438c>:0
at Game.Modding.ModManager.InitializeMods (Game.UpdateSystem updateSystem) [0x00058] in <24020fbca57c414fa88795539296438c>:0
0x00007ffcb536ea1d (UnityPlayer) UnityMain
0x00007ffcb536e798 (UnityPlayer) UnityMain
0x00007ffcb5357a89 (UnityPlayer) UnityMain
0x00007ffcb59dc23f (UnityPlayer) UnityMain
0x00007ffcb49f9688 (UnityPlayer)
Seems to happen at the main menu load or on main menu with map texture failing to load - I've isolated this error that i've seen a few times. Loading is much less uneventful with map texture replacer not loaded.